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Bicalutamide is a new antiandrogen that offers the convenience of once-daily administration, demonstrated activity in prostate cancer, and an excellent safety profile.
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In clinical trials with bicalutamide 150 mg as a single agent for prostate cancer, gynecomastia and breast pain have been reported in up to 38% and 39% of patients, respectively.
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For example, a recent analysis of numerous studies found no difference in survival between men treated with total androgen blockade and those who underwent surgical castration or took LHRH agonists alone.
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Chenoweth DM, Harki DA, Phillips JW, Dose C, Dervan PB.
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With the exception of randomized therapy, no other treatment for prostate cancer, including experimental therapy, was permitted during the trial.
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They noted that bilateral orchiectomy should be used as a benchmark for introducing the appropriate testosterone level that needs to be achieved with LHRH agonists.
In addition to the fundamental requirements of current clinical trial study design, including prospective accrual of data and documentation of pretreatment level of sexual functioning, the application of validated self-report instruments that measure sexual function should be employed.
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Tumorcellen die gevoelig zijn voor testosteron beschikken over zogenaamde Wanneer androgenen zich binden aan deze receptoren, wordt de tumor aangezet tot groei.
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It is effective at lowering testosterone levels because it inhibits secretion of LHRH from the hypothalamus (see Figure 1).
This study was followed by a randomized clinical trial by Grant (), which showed that drinking spearmint tea twice daily for 30 days (vs.
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Measurement of serum testosterone levels, in addition to serum PSA testing, should be strongly considered in clinical practice for those men on LHRH therapy, as well as those who have previously been on LHRH therapy for a period of time, to determine if and when their levels normalize.
This form of prostate cancer is lethal, and patients no longer respond to first-line androgen deprivation therapy.
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Preoperative Neoadjuvant Androgen Withdrawal Therapy in Prostate Cancer: The Canadian Experience.
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In that study, the inhibitory effect of an isopropanolic extract of black cohosh (iCR) on cell growth in androgen-sensitive LNCaP and androgen-insensitive PC-3 and DU 145 prostate cancer cells was investigated.
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Impact of Prior Use of an Androgen Receptor-Axis-Targeted (ARAT) Agent With or Without Subsequent Taxane Therapy on the Efficacy of Another ARAT Agent in Patients With Metastatic Castration-Resistant Prostate Cancer.
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